{"id":428,"date":"2025-03-15T20:23:59","date_gmt":"2025-03-15T20:23:59","guid":{"rendered":"https:\/\/rheumanext.pl\/?page_id=428"},"modified":"2026-03-14T23:28:56","modified_gmt":"2026-03-14T23:28:56","slug":"azatiopryna-aza","status":"publish","type":"page","link":"https:\/\/rheumanext.pl\/pl\/azatiopryna-aza\/","title":{"rendered":"Azatiopryna (AZA)"},"content":{"rendered":"\n<section id=\"rx-aza-monitoring-calculator\" style=\"max-width:960px;margin:0 auto;font:16px\/1.55 Inter,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI',sans-serif;color:#0f172a;\">\n  <div style=\"background:linear-gradient(180deg,#ffffff 0%,#fbfdff 100%);border:1px solid #e2e8f0;border-radius:24px;box-shadow:0 12px 30px rgba(15,23,42,.06);overflow:hidden;\">\n    <div style=\"padding:28px 28px 20px;border-bottom:1px solid #e2e8f0;background:radial-gradient(circle at top right, rgba(15,118,110,.08), transparent 32%), linear-gradient(180deg,#ffffff 0%,#f8fafc 100%);\">\n      <div style=\"display:inline-block;padding:6px 12px;border-radius:999px;background:rgba(15,118,110,.10);color:#0f766e;font-size:12px;font-weight:700;letter-spacing:.02em;text-transform:uppercase;margin-bottom:14px;\">Monitorowanie leczenia<\/div>\n      <h2 style=\"margin:0 0 10px;font-size:clamp(24px,3vw,32px);line-height:1.15;letter-spacing:-.02em;\">Azatiopryna \u2014 kwalifikator bezpiecze\u0144stwa monitorowania<\/h2>\n      <p style=\"margin:0;color:#475569;max-width:76ch;\">Interaktywny modu\u0142 do oceny bezpiecze\u0144stwa kontynuacji leczenia azatiopryn\u0105 w reumatologii. Uwzgl\u0119dnia etap terapii, wyniki bada\u0144, TPMT i czerwone flagi kliniczne.<\/p>\n    <\/div>\n\n    <div style=\"padding:28px;display:grid;gap:20px;\">\n\n      <div style=\"background:#fff;border:1px solid #e2e8f0;border-radius:20px;padding:20px;\">\n        <h3 style=\"margin:0 0 6px;font-size:18px;\">1. Etap leczenia<\/h3>\n        <p style=\"margin:0 0 16px;color:#475569;font-size:14px;\">Wybierz aktualny etap terapii, aby por\u00f3wna\u0107 cz\u0119sto\u015b\u0107 kontroli z typowym harmonogramem.<\/p>\n\n        <div style=\"display:grid;gap:12px;\">\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"radio\" name=\"rx-aza-phase\" id=\"rx-aza-phase-start\" value=\"start\" checked style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Po rozpocz\u0119ciu leczenia \/ po zmianie dawki<\/strong><br><span style=\"color:#475569;font-size:13px;\">Typowo badania co 2 tygodnie do stabilnej dawki przez 6 tygodni, potem co miesi\u0105c<\/span><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"radio\" name=\"rx-aza-phase\" id=\"rx-aza-phase-stable\" value=\"stable\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Leczenie stabilne<\/strong><br><span style=\"color:#475569;font-size:13px;\">Typowo badania co 3 miesi\u0105ce<\/span><\/span>\n          <\/label>\n        <\/div>\n\n        <div style=\"margin-top:16px;\">\n          <label for=\"rx-aza-lastlabs\" style=\"display:block;margin:0 0 8px;font-weight:700;\">Ile dni min\u0119\u0142o od ostatnich bada\u0144?<\/label>\n          <input id=\"rx-aza-lastlabs\" type=\"number\" min=\"0\" max=\"365\" step=\"1\" value=\"14\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n        <\/div>\n      <\/div>\n\n      <div style=\"background:#fff;border:1px solid #e2e8f0;border-radius:20px;padding:20px;\">\n        <h3 style=\"margin:0 0 6px;font-size:18px;\">2. TPMT<\/h3>\n        <p style=\"margin:0 0 16px;color:#475569;font-size:14px;\">Zaznacz status TPMT przed terapi\u0105.<\/p>\n\n        <div style=\"display:grid;gap:12px;\">\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"radio\" name=\"rx-aza-tpmt\" id=\"rx-aza-tpmt-normal\" value=\"normal\" checked style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>TPMT prawid\u0142owe<\/strong><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"radio\" name=\"rx-aza-tpmt\" id=\"rx-aza-tpmt-intermediate\" value=\"intermediate\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>TPMT po\u015brednie \/ obni\u017cone<\/strong><br><span style=\"color:#475569;font-size:13px;\">Wymaga mniejszej dawki i \u015bcis\u0142ego nadzoru<\/span><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"radio\" name=\"rx-aza-tpmt\" id=\"rx-aza-tpmt-absent\" value=\"absent\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Brak \/ bardzo niska aktywno\u015b\u0107 TPMT<\/strong><br><span style=\"color:#475569;font-size:13px;\">To czerwona flaga bezpiecze\u0144stwa<\/span><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"radio\" name=\"rx-aza-tpmt\" id=\"rx-aza-tpmt-unknown\" value=\"unknown\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Nieznane \/ brak wyniku TPMT<\/strong><\/span>\n          <\/label>\n        <\/div>\n      <\/div>\n\n      <div style=\"background:#fff;border:1px solid #e2e8f0;border-radius:20px;padding:20px;\">\n        <h3 style=\"margin:0 0 6px;font-size:18px;\">3. Wyniki bada\u0144<\/h3>\n        <p style=\"margin:0 0 16px;color:#475569;font-size:14px;\">Wpisz najbardziej aktualne wyniki.<\/p>\n\n        <div style=\"display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px;\">\n          <div>\n            <label for=\"rx-aza-wbc\" style=\"display:block;margin:0 0 8px;font-weight:700;\">WBC (\u00d710\u2079\/L)<\/label>\n            <input id=\"rx-aza-wbc\" type=\"number\" min=\"0\" max=\"50\" step=\"0.1\" value=\"5.0\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div>\n            <label for=\"rx-aza-neut\" style=\"display:block;margin:0 0 8px;font-weight:700;\">Neutrofile (\u00d710\u2079\/L)<\/label>\n            <input id=\"rx-aza-neut\" type=\"number\" min=\"0\" max=\"30\" step=\"0.1\" value=\"2.5\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div>\n            <label for=\"rx-aza-eos\" style=\"display:block;margin:0 0 8px;font-weight:700;\">Eozynofile (\u00d710\u2079\/L)<\/label>\n            <input id=\"rx-aza-eos\" type=\"number\" min=\"0\" max=\"10\" step=\"0.1\" value=\"0.1\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div>\n            <label for=\"rx-aza-plt\" style=\"display:block;margin:0 0 8px;font-weight:700;\">P\u0142ytki (\u00d710\u2079\/L)<\/label>\n            <input id=\"rx-aza-plt\" type=\"number\" min=\"0\" max=\"1000\" step=\"1\" value=\"220\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div>\n            <label for=\"rx-aza-alb\" style=\"display:block;margin:0 0 8px;font-weight:700;\">Albumina (g\/L)<\/label>\n            <input id=\"rx-aza-alb\" type=\"number\" min=\"0\" max=\"60\" step=\"1\" value=\"40\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div>\n            <label for=\"rx-aza-mcv\" style=\"display:block;margin:0 0 8px;font-weight:700;\">MCV (fL)<\/label>\n            <input id=\"rx-aza-mcv\" type=\"number\" min=\"50\" max=\"140\" step=\"1\" value=\"92\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div>\n            <label for=\"rx-aza-altast\" style=\"display:block;margin:0 0 8px;font-weight:700;\">ALT \/ AST \u2014 wy\u017csza warto\u015b\u0107 (U\/L)<\/label>\n            <input id=\"rx-aza-altast\" type=\"number\" min=\"0\" max=\"1000\" step=\"1\" value=\"24\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div>\n            <label for=\"rx-aza-egfr\" style=\"display:block;margin:0 0 8px;font-weight:700;\">eGFR (ml\/min\/1,73 m\u00b2)<\/label>\n            <input id=\"rx-aza-egfr\" type=\"number\" min=\"0\" max=\"150\" step=\"1\" value=\"90\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n\n          <div style=\"grid-column:1\/-1;\">\n            <label for=\"rx-aza-creatchange\" style=\"display:block;margin:0 0 8px;font-weight:700;\">Zmiana kreatyniny wzgl\u0119dem warto\u015bci wyj\u015bciowej (%)<\/label>\n            <input id=\"rx-aza-creatchange\" type=\"number\" min=\"-50\" max=\"300\" step=\"1\" value=\"0\" style=\"width:100%;box-sizing:border-box;padding:14px 16px;border:1px solid #cbd5e1;border-radius:14px;font:inherit;\">\n          <\/div>\n        <\/div>\n      <\/div>\n\n      <div style=\"background:#fff;border:1px solid #e2e8f0;border-radius:20px;padding:20px;\">\n        <h3 style=\"margin:0 0 6px;font-size:18px;\">4. Czerwone flagi kliniczne<\/h3>\n        <p style=\"margin:0 0 16px;color:#475569;font-size:14px;\">Zaznacz obecne objawy lub sytuacje kliniczne.<\/p>\n\n        <div style=\"display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px;\">\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-infection\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Aktywna infekcja \/ wysoka gor\u0105czka<\/strong><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-flu\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Ci\u0119\u017ckie objawy grypopodobne<\/strong><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-bruising\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>\u0141atwe siniaczenie \/ krwawienia<\/strong><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-jaundice\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>\u017b\u00f3\u0142taczka \/ podejrzenie uszkodzenia w\u0105troby<\/strong><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-rash\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Nowa wysypka \/ reakcja nadwra\u017cliwo\u015bci<\/strong><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-vomiting\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Uporczywe wymioty \/ ci\u0119\u017cka nietolerancja<\/strong><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-interaction\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Nowy lek o istotnym ryzyku interakcji<\/strong><br><span style=\"color:#475569;font-size:13px;\">np. allopurynol<\/span><\/span>\n          <\/label>\n\n          <label style=\"display:flex;align-items:flex-start;gap:10px;padding:14px;border:1px solid #e2e8f0;border-radius:16px;background:#fff;cursor:pointer;\">\n            <input type=\"checkbox\" id=\"rx-aza-pregnancy\" style=\"margin-top:3px;accent-color:#0f766e;\">\n            <span><strong>Ci\u0105\u017ca \/ planowanie ci\u0105\u017cy \u2014 wymaga om\u00f3wienia<\/strong><\/span>\n          <\/label>\n        <\/div>\n      <\/div>\n\n      <div style=\"display:flex;flex-wrap:wrap;gap:12px;margin-top:2px;\">\n        <button\n          type=\"button\"\n          id=\"rx-aza-calc-btn\"\n          style=\"appearance:none;border:0;border-radius:16px;padding:14px 18px;background:linear-gradient(180deg,#0f766e 0%,#115e59 100%);color:#fff;font:inherit;font-weight:700;cursor:pointer;box-shadow:0 12px 24px rgba(15,118,110,.22);display:inline-flex;align-items:center;justify-content:center;min-width:180px;\"\n        >Oblicz wynik<\/button>\n\n        <button\n          type=\"button\"\n          id=\"rx-aza-clear-btn\"\n          style=\"appearance:none;border:1px solid #cbd5e1;border-radius:16px;padding:14px 18px;background:#fff;color:#0f172a;font:inherit;font-weight:700;cursor:pointer;display:inline-flex;align-items:center;justify-content:center;\"\n        >Wyczy\u015b\u0107<\/button>\n      <\/div>\n\n      <div id=\"rx-aza-result\" style=\"display:block;border-radius:20px;padding:20px;border:1px solid #e2e8f0;background:#f8fafc;\">\n        <p id=\"rx-aza-result-title\" style=\"margin:0 0 8px;font-size:18px;line-height:1.3;font-weight:800;color:#0f172a;\">Wynik pojawi si\u0119 tutaj<\/p>\n        <p id=\"rx-aza-result-text\" style=\"margin:0 0 8px;\">Uzupe\u0142nij etap leczenia, TPMT, wyniki i czerwone flagi, a nast\u0119pnie kliknij \u201eOblicz wynik\u201d.<\/p>\n        <p id=\"rx-aza-result-note\" style=\"margin:0;color:#475569;font-size:14px;\">Modu\u0142 bezpiecze\u0144stwa monitorowania azatiopryny: pokazuje brak oczywistych czerwonych flag, potrzeb\u0119 weryfikacji lub piln\u0105 flag\u0119 bezpiecze\u0144stwa.<\/p>\n      <\/div>\n\n      <div style=\"border:1px solid #e2e8f0;background:linear-gradient(180deg,#ffffff 0%,#f8fafc 100%);border-radius:18px;padding:16px 18px;color:#475569;font-size:14px;\">\n        <strong style=\"color:#0f172a;\">Uwaga:<\/strong> to narz\u0119dzie wspiera monitorowanie bezpiecze\u0144stwa leczenia azatiopryn\u0105 i nie zast\u0119puje decyzji klinicznej. Przy azatioprynie szczeg\u00f3lnie wa\u017cne s\u0105 TPMT, morfologia, w\u0105troba, nerki i infekcje.\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<script>\n(function () {\n  var calcBtn = document.getElementById('rx-aza-calc-btn');\n  var clearBtn = document.getElementById('rx-aza-clear-btn');\n\n  if (!calcBtn || !clearBtn) return;\n\n  function readValue(id, min, max, fallback) {\n    var v = parseFloat(document.getElementById(id).value);\n    if (isNaN(v)) v = fallback;\n    if (v < min) v = min;\n    if (v > max) v = max;\n    return v;\n  }\n\n  function expectedDays() {\n    if (document.getElementById('rx-aza-phase-start').checked) return 31;\n    return 92;\n  }\n\n  calcBtn.addEventListener('click', function () {\n    var wbc = readValue('rx-aza-wbc', 0, 50, 0);\n    var neut = readValue('rx-aza-neut', 0, 30, 0);\n    var eos = readValue('rx-aza-eos', 0, 10, 0);\n    var plt = readValue('rx-aza-plt', 0, 1000, 0);\n    var alb = readValue('rx-aza-alb', 0, 60, 0);\n    var mcv = readValue('rx-aza-mcv', 50, 140, 0);\n    var altast = readValue('rx-aza-altast', 0, 1000, 0);\n    var egfr = readValue('rx-aza-egfr', 0, 150, 0);\n    var creatChange = readValue('rx-aza-creatchange', -50, 300, 0);\n    var lastLabs = readValue('rx-aza-lastlabs', 0, 365, 0);\n\n    var tpmtAbsent = document.getElementById('rx-aza-tpmt-absent').checked;\n    var tpmtIntermediate = document.getElementById('rx-aza-tpmt-intermediate').checked;\n    var tpmtUnknown = document.getElementById('rx-aza-tpmt-unknown').checked;\n\n    var infection = document.getElementById('rx-aza-infection').checked;\n    var flu = document.getElementById('rx-aza-flu').checked;\n    var bruising = document.getElementById('rx-aza-bruising').checked;\n    var jaundice = document.getElementById('rx-aza-jaundice').checked;\n    var rash = document.getElementById('rx-aza-rash').checked;\n    var vomiting = document.getElementById('rx-aza-vomiting').checked;\n    var interaction = document.getElementById('rx-aza-interaction').checked;\n    var pregnancy = document.getElementById('rx-aza-pregnancy').checked;\n\n    var redFlags = [];\n    var yellowFlags = [];\n\n    if (tpmtAbsent) redFlags.push('brak \/ bardzo niska aktywno\u015b\u0107 TPMT');\n    if (wbc < 3.5) redFlags.push('WBC < 3,5 \u00d710\u2079\/L');\n    if (neut < 1.6) redFlags.push('neutrofile < 1,6 \u00d710\u2079\/L');\n    if (eos > 0.5) redFlags.push('eozynofile > 0,5 \u00d710\u2079\/L');\n    if (plt < 140) redFlags.push('p\u0142ytki < 140 \u00d710\u2079\/L');\n    if (alb < 30) redFlags.push('albumina < 30 g\/L');\n    if (mcv > 105) redFlags.push('MCV > 105 fL');\n    if (altast > 100) redFlags.push('ALT\/AST > 100 U\/L');\n    if (creatChange > 30) redFlags.push('kreatynina wzros\u0142a > 30% wzgl\u0119dem wyj\u015bciowej');\n    if (egfr < 60) redFlags.push('eGFR < 60 ml\/min\/1,73 m\u00b2');\n    if (infection) redFlags.push('aktywna infekcja \/ wysoka gor\u0105czka');\n    if (flu) redFlags.push('ci\u0119\u017ckie objawy grypopodobne');\n    if (bruising) redFlags.push('\u0142atwe siniaczenie \/ krwawienia');\n    if (jaundice) redFlags.push('\u017c\u00f3\u0142taczka \/ podejrzenie uszkodzenia w\u0105troby');\n\n    if (tpmtIntermediate) yellowFlags.push('TPMT po\u015brednie \/ obni\u017cone \u2014 wymaga dawki redukowanej i \u015bcis\u0142ego nadzoru');\n    if (tpmtUnknown) yellowFlags.push('brak wyniku TPMT');\n    if (rash) yellowFlags.push('nowa wysypka \/ reakcja nadwra\u017cliwo\u015bci');\n    if (vomiting) yellowFlags.push('uporczywe wymioty \/ ci\u0119\u017cka nietolerancja');\n    if (interaction) yellowFlags.push('mo\u017cliwa istotna interakcja lekowa');\n    if (pregnancy) yellowFlags.push('ci\u0105\u017ca \/ planowanie ci\u0105\u017cy wymaga om\u00f3wienia z lekarzem');\n    if (lastLabs > expectedDays()) yellowFlags.push('badania wykonano p\u00f3\u017aniej ni\u017c typowy interwa\u0142 dla tego etapu leczenia');\n\n    var result = document.getElementById('rx-aza-result');\n    var title = document.getElementById('rx-aza-result-title');\n    var text = document.getElementById('rx-aza-result-text');\n    var note = document.getElementById('rx-aza-result-note');\n\n    result.style.display = 'block';\n\n    if (redFlags.length > 0) {\n      result.style.background = '#fef2f2';\n      result.style.border = '1px solid #fecaca';\n      title.style.color = '#991b1b';\n      title.innerHTML = 'Czerwona flaga bezpiecze\u0144stwa';\n      text.innerHTML = 'Ten modu\u0142 wykry\u0142 istotne nieprawid\u0142owo\u015bci wymagaj\u0105ce pilnej weryfikacji i zwykle odroczenia \/ wstrzymania dalszej decyzji do kontaktu z lekarzem prowadz\u0105cym.';\n      note.innerHTML = 'Wykryte problemy: ' + redFlags.join('; ') + (yellowFlags.length ? '. Dodatkowo: ' + yellowFlags.join('; ') : '') + '.';\n    } else if (yellowFlags.length > 0) {\n      result.style.background = '#fffbeb';\n      result.style.border = '1px solid #fde68a';\n      title.style.color = '#92400e';\n      title.innerHTML = 'Wymaga weryfikacji';\n      text.innerHTML = 'Brak oczywistych czerwonych flag w podanych progach, ale s\u0105 elementy wymagaj\u0105ce kontroli klinicznej lub organizacyjnej przed dalszym planem leczenia.';\n      note.innerHTML = 'Do weryfikacji: ' + yellowFlags.join('; ') + '.';\n    } else {\n      result.style.background = '#f0fdf4';\n      result.style.border = '1px solid #bbf7d0';\n      title.style.color = '#166534';\n      title.innerHTML = 'Brak oczywistych czerwonych flag w tym module';\n      text.innerHTML = 'W podanych danych nie wykryto prog\u00f3w alarmowych u\u017cytych w tym kwalifikatorze.';\n      note.innerHTML = 'Pami\u0119taj o typowym harmonogramie kontroli dla tego etapu terapii oraz o ocenie trend\u00f3w wynik\u00f3w, nie tylko warto\u015bci pojedynczych.';\n    }\n  });\n\n  clearBtn.addEventListener('click', function () {\n    document.getElementById('rx-aza-phase-start').checked = true;\n    document.getElementById('rx-aza-lastlabs').value = 14;\n    document.getElementById('rx-aza-tpmt-normal').checked = true;\n    document.getElementById('rx-aza-wbc').value = 5.0;\n    document.getElementById('rx-aza-neut').value = 2.5;\n    document.getElementById('rx-aza-eos').value = 0.1;\n    document.getElementById('rx-aza-plt').value = 220;\n    document.getElementById('rx-aza-alb').value = 40;\n    document.getElementById('rx-aza-mcv').value = 92;\n    document.getElementById('rx-aza-altast').value = 24;\n    document.getElementById('rx-aza-egfr').value = 90;\n    document.getElementById('rx-aza-creatchange').value = 0;\n    document.getElementById('rx-aza-infection').checked = false;\n    document.getElementById('rx-aza-flu').checked = false;\n    document.getElementById('rx-aza-bruising').checked = false;\n    document.getElementById('rx-aza-jaundice').checked = false;\n    document.getElementById('rx-aza-rash').checked = false;\n    document.getElementById('rx-aza-vomiting').checked = false;\n    document.getElementById('rx-aza-interaction').checked = false;\n    document.getElementById('rx-aza-pregnancy').checked = false;\n\n    document.getElementById('rx-aza-result').style.display = 'block';\n    document.getElementById('rx-aza-result').style.background = '#f8fafc';\n    document.getElementById('rx-aza-result').style.border = '1px solid #e2e8f0';\n    document.getElementById('rx-aza-result-title').style.color = '#0f172a';\n    document.getElementById('rx-aza-result-title').innerHTML = 'Wynik pojawi si\u0119 tutaj';\n    document.getElementById('rx-aza-result-text').innerHTML = 'Uzupe\u0142nij etap leczenia, TPMT, wyniki i czerwone flagi, a nast\u0119pnie kliknij \u201eOblicz wynik\u201d.';\n    document.getElementById('rx-aza-result-note').innerHTML = 'Modu\u0142 bezpiecze\u0144stwa monitorowania azatiopryny: pokazuje brak oczywistych czerwonych flag, potrzeb\u0119 weryfikacji lub piln\u0105 flag\u0119 bezpiecze\u0144stwa.';\n  });\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Monitorowanie leczenia Azatiopryna \u2014 kwalifikator bezpiecze\u0144stwa monitorowania Interaktywny modu\u0142 do oceny bezpiecze\u0144stwa kontynuacji leczenia azatiopryn\u0105 w reumatologii. Uwzgl\u0119dnia etap terapii, wyniki bada\u0144, TPMT i czerwone flagi kliniczne. 1. Etap leczenia Wybierz aktualny etap terapii, aby por\u00f3wna\u0107 cz\u0119sto\u015b\u0107 kontroli z typowym harmonogramem. Po rozpocz\u0119ciu leczenia \/ po zmianie dawkiTypowo badania co 2 tygodnie do stabilnej dawki&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-428","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/pages\/428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/comments?post=428"}],"version-history":[{"count":4,"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/pages\/428\/revisions"}],"predecessor-version":[{"id":1202,"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/pages\/428\/revisions\/1202"}],"wp:attachment":[{"href":"https:\/\/rheumanext.pl\/pl\/wp-json\/wp\/v2\/media?parent=428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}